Authors
David L Perez, David R Vago, Hong Pan, James Root, Oliver Tuescher, Benjamin H Fuchs, Lorene Leung, Jane Epstein, Nicole M Cain, John F Clarkin, Mark F Lenzenweger, Otto F Kernberg, Kenneth N Levy, David A Silbersweig, Emily Stern
Publication date
2016/1
Journal
Psychiatry and clinical neurosciences
Volume
70
Issue
1
Pages
51-61
Description
Aims
Borderline personality disorder (BPD) is characterized by self‐regulation deficits, including impulsivity and affective lability. Transference‐focused psychotherapy (TFP) is an evidence‐based treatment proven to reduce symptoms across multiple cognitive–emotional domains in BPD. This pilot study aimed to investigate neural activation associated with, and predictive of, clinical improvement in emotional and behavioral regulation in BPD following TFP.
Methods
BPD subjects (n = 10) were scanned pre‐ and post‐TFP treatment using a within‐subjects design. A disorder‐specific emotional–linguistic go/no‐go functional magnetic resonance imaging paradigm was used to probe the interaction between negative emotional processing and inhibitory control.
Results
Analyses demonstrated significant treatment‐related effects with relative increased dorsal prefrontal (dorsal anterior cingulate, dorsolateral …
Scholar articles
DL Perez, DR Vago, H Pan, J Root, O Tuescher… - Psychiatry and clinical neurosciences, 2016