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This paper reports the results of a two‐phase study that explores new venture creation within the context of an entrepreneurial system. First, a genealogy of high‐technology companies is presented depicting a high spin‐off rate resulting from the presence of seven incubator organizations. Second, semantic structure analysis based on semi‐structured interviews with founders is used to develop a taxonomy. This taxonomy depicts the relationship among components in one entrepreneurial system, Boulder County, Colorado, that encourages, supports, and enhances regional entrepreneurial activity. Findings indicate that incubator organizations, spin‐offs, informal and formal networks, the physical infrastructure, and the culture of the region are related uniquely and interact to form a system conducive for dense high‐technology entrepreneurial activity. Additionally, greater rates of new venture formation were found …