Authors
Lynn Ang, Sejal VG Gunaratnam, Yiyuan Huang, Kara R Mizokami-Stout, Catherine Martin, Jacob Reiss, Aaron Burant, Alexi Vasbinder, Christopher Launius, Lili Zhao, Eva L Feldman, Salim Hayek, Rodica Pop-Busui
Publication date
2022/6/1
Journal
Diabetes
Volume
71
Issue
Supplement_1
Publisher
American Diabetes Association
Description
Objective: We aimed to assess the role of chronic inflammation in the pathogenesis of cardiovascular autonomic neuropathy (CAN), a serious complication of type 1 diabetes (T1D).
Methods: We leveraged an ongoing randomized, placebo-controlled clinical trial targeting inflammation with salsalate in individuals with T1D, to measure a panel of 40 inflammatory markers (Figure) in baseline samples. Measures of CAN included standardized cardiovascular autonomic reflex tests (CARTs)(E/I, Valsalva, 30/15 ratios) and indices of heart rate variability (HRV). We used Spearman-rank to assess the correlations between inflammatory markers and CAN measures, and linear regression to adjust for age and hemoglobin A1c.
Results: The Figure displays the correlation between biomarkers and CAN measures in 58 T1D participants (mean age 51±13 years, and HbA1c 8.4±1.8%). Amongst all biomarkers, we noted a singular …
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Scholar articles
L Ang, SVG Gunaratnam, Y Huang, KR Mizokami-Stout… - Diabetes, 2022