Authors
VC Russo, PD Gluckman, EL Feldman, GA Werther
Publication date
2005/12/1
Source
Endocrine reviews
Volume
26
Issue
7
Pages
916-943
Publisher
Oxford University Press
Description
In recent years, much interest has been devoted to defining the role of the IGF system in the nervous system. The ubiquitous IGFs, their cell membrane receptors, and their carrier binding proteins, the IGFBPs, are expressed early in the development of the nervous system and are therefore considered to play a key role in these processes. In vitro studies have demonstrated that the IGF system promotes differentiation and proliferation and sustains survival, preventing apoptosis of neuronal and brain derived cells. Furthermore, studies of transgenic mice overexpressing components of the IGF system or mice with disruptions of the same genes have clearly shown that the IGF system plays a key role in vivo.
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Scholar articles
VC Russo, PD Gluckman, EL Feldman, GA Werther - Endocrine reviews, 2005