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One of the key factors that hinders integration of distributed, heterogeneous information systems is the lack of a formal basis for modeling the complex, structured knowledge that is to be exchanged. To alleviate this situation, we present an approach based on core ontologies. Core ontologies are characterized by a high degree of axiomatization and formal precision. This is achieved by basing on a foundational ontology. In addition, core ontologies should follow a pattern-oriented design approach. By this, they are modular and extensible. Core ontologies allow for reusing the structured knowledge they define as well as integrating existing domain knowledge. The structured knowledge of the core ontologies is clearly separated from the domain-specific knowledge. Such core ontologies allow for both formally conceptualize their particular fields and to be flexibly combined to cover the needs of concrete, complex …