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To explore attitudes of clinical and molecular geneticists about the implementation of multi-disease or expanded carrier screening (ECS) for monogenic recessive disorders.

Qualitative; semistructured interviews.

In person or via Skype. Interviews were audiorecorded and transcribed verbatim.

European clinical and molecular geneticists with expertise in carrier screening (N = 16).

Inductive content analysis was used to identify common content categories in the data.

Participants recognized important benefits of ECS, but they also identified major challenges, including limited benefit of ECS for most couples in the general population, lack of knowledge on carrier screening among nongenetic health care providers and the general public, potential negative implications of ECS for society, and limited economic resources. Participants favored an evidence-based approach …