Authors
Jae-Hoon Ko, Hyeri Seok, Sun Young Cho, Young Eun Ha, Jin Yang Baek, So Hyun Kim, Yae-Jean Kim, Jin Kyeong Park, Chi Ryang Chung, Eun-Suk Kang, Duck Cho, Marcel A Müller, Christian Drosten, Cheol-In Kang, Doo Ryeon Chung, Jae-Hoon Song, Kyong Ran Peck
Publication date
2018/10
Source
Antiviral therapy
Volume
23
Issue
7
Pages
617-622
Publisher
Sage Publications
Description
Background
The effects of convalescent plasma (CP) infusion, one of the treatment options for severe Middle East respiratory syndrome coronavirus (MERS-CoV) infections, have not yet been evaluated.
Methods
Serological responses of CP-infused MERS patients during the 2015 Korean MERS outbreak at a tertiary care centre were evaluated. Serological activity was evaluated with anti-MERS-CoV enzyme-linked immunosorbent assay (ELISA) immunoglobulin (Ig)G, ELISA IgA, immunofluorescence assay IgM and plaque reduction neutralization test (PRNT). Donor plasma and one or two recipient's serum samples per week of illness including one taken the day after each CP infusion were evaluated. For sensitivity and specificity analysis of ELISA IgG in predicting neutralization activity, a data set of 138 previously evaluated MERS-CoV-infected patients was used.
Results
Three of thirteen MERS patients with …
Scholar articles
JH Ko, H Seok, SY Cho, YE Ha, JY Baek, SH Kim… - 2018