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This paper modifies the traditional representation of the water–food–energy (WFE) nexus by emphasizing the flows or influences between components. This allows a better representation of the dynamic nature of the WFE nexus in response to global change drivers. It applies a conceptual figure to synthesize the status and future challenges of the nexus in four regions of Chile that are currently under pressure due to climate variability, relative water scarcity and strong competition for water from different sectors.