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Few studies examining the link between personality and alcohol use have adopted a comprehensive modeling framework to take into account individuals’ profiles across multiple personality traits. In this study, latent profile analysis (LPA) was applied to a national sample of young adults in the United States to identify subgroups defined by their profiles of mean scores on the Neuroticism, Extraversion, Openness, Agreeableness, and Conscientiousness personality factors. Personality profiles were then used to predict heavy drinking. Five profiles were identified: Reserved, Rigid, Confident, Ordinary, and Resilient. Compared to individuals in the Ordinary profile, those with Reserved and Resilient profiles were at increased risk of frequent heavy drinking. These findings suggest which comprehensive personality profiles may place individuals at risk for problematic alcohol-related outcomes.