Authors
Elena M Bonke, Michaela V Bonfert, Stefan M Hillmann, Johanna Seitz-Holland, Malo Gaubert, Tim LT Wiegand, Alberto De Luca, Kang Ik K Cho, Stian B Sandmo, Eukyung Yhang, Yorghos Tripodis, Caroline Seer, David Kaufmann, Elisabeth Kaufmann, Marc Muehlmann, Jolien Gooijers, Alexander P Lin, Alexander Leemans, Stephan P Swinnen, Roald Bahr, Martha E Shenton, Ofer Pasternak, Uta Tacke, Florian Heinen, Inga K Koerte
Publication date
2023/5/1
Journal
Cerebral Cortex
Volume
33
Issue
9
Pages
5547-5556
Publisher
Oxford University Press
Description
Neurological soft signs (NSS) are minor deviations in motor performance. During childhood and adolescence, NSS are examined for functional motor phenotyping to describe development, to screen for comorbidities, and to identify developmental vulnerabilities. Here, we investigate underlying brain structure alterations in association with NSS in physically trained adolescents. Male adolescent athletes (n = 136, 13–16 years) underwent a standardized neurological examination including 28 tests grouped into 6 functional clusters. Non-optimal performance in at least 1 cluster was rated as NSS (NSS+ group). Participants underwent T1- and diffusion-weighted magnetic resonance imaging. Cortical volume, thickness, and local gyrification were calculated using Freesurfer. Measures of white matter microstructure (Free-water (FW), FW-corrected fractional anisotropy (FAt), axial and radial diffusivity (ADt, RDt …
Total citations
20233
Scholar articles
EM Bonke, MV Bonfert, SM Hillmann, J Seitz-Holland… - Cerebral Cortex, 2023