Authors
Roelof van Ewijk, Cyrano Chatziantoniou, Madeleine Adams, Patrizia Bertolini, Gianni Bisogno, Amine Bouhamama, Pablo Caro-Dominguez, Valerie Charon, Ana Coma, Rana Dandis, Christine Devalck, Giulia De Donno, Andrea Ferrari, Marta Fiocco, Soledad Gallego, Chiara Giraudo, Heidi Glosli, Simone AJ Ter Horst, Meriel Jenney, Willemijn M Klein, Alexander Leemans, Julie Leseur, Henry C Mandeville, Kieran McHugh, Johannes HM Merks, Veronique Minard-Colin, Salma Moalla, Carlo Morosi, Daniel Orbach, Lil-Sofie Ording Muller, Erika Pace, Pier Luigi Di Paolo, Katia Perruccio, Lucia Quaglietta, Marleen Renard, Rick R van Rijn, Antonio Ruggiero, Sara I Sirvent, Alberto De Luca, Reineke A Schoot
Publication date
2023/11
Journal
Pediatric radiology
Volume
53
Issue
12
Pages
2539-2551
Publisher
Springer Berlin Heidelberg
Description
Objective
To investigate the feasibility of diffusion-weighted magnetic resonance imaging (DW-MRI) as a predictive imaging marker after neoadjuvant chemotherapy in patients with rhabdomyosarcoma.
Material and methods
We performed a multicenter retrospective study including pediatric, adolescent and young adult patients with rhabdomyosarcoma, Intergroup Rhabdomyosarcoma Study group III/IV, treated according to the European paediatric Soft tissue sarcoma Study Group (EpSSG) RMS2005 or MTS2008 studies. DW-MRI was performed according to institutional protocols. We performed two-dimensional single-slice tumor delineation. Areas of necrosis or hemorrhage were delineated to be excluded in the primary analysis. Mean, median and 5th and 95th apparent diffusion coefficient (ADC) were extracted.
Results
Of 134 included patients, 82 had measurable tumor at diagnosis and response and DW-MRI …
Scholar articles
R van Ewijk, C Chatziantoniou, M Adams, P Bertolini… - Pediatric radiology, 2023