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We report the discovery by the Wide-field Infrared Survey Explorer (WISE) of the z= 2.452 source WISE J181417. 29+ 341224.9, the first hyperluminous source found in the WISE survey. WISE 1814+ 3412 is also the prototype for an all-sky sample of∼ 1000 extremely luminous" W1W2-dropouts"(sources faint or undetected by WISE at 3.4 and 4.6 μm and well detected at 12 or 22 μm). The WISE data and a 350 μm detection give a minimum bolometric luminosity of 3.7× 10 13 L☉, with∼ 10 14 L☉ plausible. Follow-up images reveal four nearby sources: a QSO and two Lyman break galaxies (LBGs) at z= 2.45, and an M dwarf star. The brighter LBG dominates the bolometric emission. Gravitational lensing is unlikely given the source locations and their different spectra and colors. The dominant LBG spectrum indicates a star formation rate∼ 300 M☉ yr− 1, accounting for≲ 10% of the bolometric luminosity. Strong 22 …