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We present a determination of the Hubble constant, H 0, from measurements of the Sunyaev-Zeldovich effect in an orientation-unbiased sample of seven z< 0.1 galaxy clusters. With improved X-ray models and a more accurate 32 GHz calibration, we obtain H 0= 64±14 sys km s-1 Mpc-1 for a standard cold dark matter (CDM) cosmology, or H 0= 66±15 sys km s-1 Mpc-1 for a flat Λ CDM cosmology. In combination with X-ray cluster measurements and the big bang nucleosynthesis value for Ω B, we find Ω M= 0.32±0.05.