Authors
Yves A DeClerck, TD Yean, Y Lee, JM Tomich, KE Langley
Publication date
1993/1/1
Journal
Biochemical Journal
Volume
289
Issue
Pt 1
Pages
65
Publisher
Portland Press Ltd
Description
Analysis of the functional domain of tissue inhibitor of metallo-proteinases-2 (TIMP-2) was performed using limited proteolytic degradation with trypsin. This treatment generated a 13.5 kDa fragment which was purified and shown to consist of an uncleaved N-terminal region extending from residue 1 to residue 132. The fragment retains the ability to inhibit activated interstitial collagenase and to block the autocatalytic activation of procollagenase.
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Scholar articles
YA DeClerck, TD Yean, Y Lee, JM Tomich, KE Langley - Biochemical Journal, 1993