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Hyperglycaemia in COVID-19 is a strong predictor of worsening the prognosis and increasing the possibility of death. 1, 2 Therefore, understanding the process behind this evidence is of great interest. It is known that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may infect endocrine pancreas cells via their expression of angiotensin-converting enzyme-2 (ACE-2) receptors. 3 It is possible that the pancreatic damage caused by the virus, and the resultant impairment in beta-cell insulin secretion, may worsen pre-existing diabetes or determine the appearance of hyperglycaemia in non-diabetes. 3 Interestingly, the 2003 SARS, which was caused by another coronavirus closely related to COVID-19, also produced a transient impairment of pancreatic islet cell function. 4 Cytokines, including IL-6 and TNF-alpha, have been found to be elevated in patients with severe COVID-19. 5 Inflammation …