Authors
Lili Liu, Atlas Khan, Elena Sanchez-Rodriguez, Francesca Zanoni, Yifu Li, Nicholas Steers, Olivia Balderes, Junying Zhang, Priya Krithivasan, Robert A LeDesma, Clara Fischman, Scott J Hebbring, John B Harley, Halima Moncrieffe, Leah C Kottyan, Bahram Namjou-Khales, Theresa L Walunas, Rachel Knevel, Soumya Raychaudhuri, Elizabeth W Karlson, Joshua C Denny, Ian B Stanaway, David Crosslin, Thomas Rauen, Jürgen Floege, Frank Eitner, Zina Moldoveanu, Colin Reily, Barbora Knoppova, Stacy Hall, Justin T Sheff, Bruce A Julian, Robert J Wyatt, Hitoshi Suzuki, Jingyuan Xie, Nan Chen, Xujie Zhou, Hong Zhang, Lennart Hammarström, Alexander Viktorin, Patrik KE Magnusson, Ning Shang, George Hripcsak, Chunhua Weng, Tatjana Rundek, Mitchell SV Elkind, Elizabeth C Oelsner, R Graham Barr, Iuliana Ionita-Laza, Jan Novak, Ali G Gharavi, Krzysztof Kiryluk
Publication date
2022/11/11
Journal
Nature communications
Volume
13
Issue
1
Pages
6859
Publisher
Nature Publishing Group UK
Description
Immunoglobulin A (IgA) mediates mucosal responses to food antigens and the intestinal microbiome and is involved in susceptibility to mucosal pathogens, celiac disease, inflammatory bowel disease, and IgA nephropathy. We performed a genome-wide association study of serum IgA levels in 41,263 individuals of diverse ancestries and identified 20 genome-wide significant loci, including 9 known and 11 novel loci. Co-localization analyses with expression QTLs prioritized candidate genes for 14 of 20 significant loci. Most loci encoded genes that produced immune defects and IgA abnormalities when genetically manipulated in mice. We also observed positive genetic correlations of serum IgA levels with IgA nephropathy, type 2 diabetes, and body mass index, and negative correlations with celiac disease, inflammatory bowel disease, and several infections. Mendelian randomization supported elevated serum …
Total citations
Scholar articles
L Liu, A Khan, E Sanchez-Rodriguez, F Zanoni, Y Li… - Nature communications, 2022