Authors
Douglas F Easton, Karen A Pooley, Alison M Dunning, Paul DP Pharoah, Deborah Thompson, Dennis G Ballinger, Jeffery P Struewing, Jonathan Morrison, Helen Field, Robert Luben, Nicholas Wareham, Shahana Ahmed, Catherine S Healey, Richard Bowman, SEARCH collaborators Luccarini Craig 61 Conroy Don 61 Shah Mitul 61 Munday Hannah 61 Jordan Clare 61 Perkins Barbara 61 West Judy 61 Redman Karen 61 Driver Kristy 61, Kerstin B Meyer, Christopher A Haiman, Laurence K Kolonel, Brian E Henderson, Loic Le Marchand, Paul Brennan, Suleeporn Sangrajrang, Valerie Gaborieau, Fabrice Odefrey, Chen-Yang Shen, Pei-Ei Wu, Hui-Chun Wang, Diana Eccles, D Gareth Evans, Julian Peto, Olivia Fletcher, Nichola Johnson, Sheila Seal, Michael R Stratton, Nazneen Rahman, Georgia Chenevix-Trench, Stig E Bojesen, Børge G Nordestgaard, Christen K Axelsson, Montserrat Garcia-Closas, Louise Brinton, Stephen Chanock, Jolanta Lissowska, Beata Peplonska, Heli Nevanlinna, Rainer Fagerholm, Hannaleena Eerola, Daehee Kang, Keun-Young Yoo, Dong-Young Noh, Sei-Hyun Ahn, David J Hunter, Susan E Hankinson, David G Cox, Per Hall, Sara Wedren, Jianjun Liu, Yen-Ling Low, Natalia Bogdanova, Peter Schürmann, Thilo Dörk, Rob AEM Tollenaar, Catharina E Jacobi, Peter Devilee, Jan GM Klijn, Alice J Sigurdson, Michele M Doody, Bruce H Alexander, Jinghui Zhang, Angela Cox, Ian W Brock, Gordon MacPherson, Malcolm WR Reed, Fergus J Couch, Ellen L Goode, Janet E Olson, Hanne Meijers-Heijboer, Ans van den Ouweland, André Uitterlinden, Fernando Rivadeneira, Roger L Milne, Gloria Ribas, Anna Gonzalez-Neira, Javier Benitez, John L Hopper, Margaret McCredie, Melissa Southey, Graham G Giles, Chris Schroen, Christina Justenhoven, Hiltrud Brauch, Ute Hamann, Yon-Dschun Ko, Amanda B Spurdle, Jonathan Beesley, Xiaoqing Chen, AOCS Management Group Bowtell David 146 Green Adele 82 deFazio Anna 147 Chenevix-Trench Georgia 82 Gertig Dorota 111 Webb Penny 82, Arto Mannermaa, Veli-Matti Kosma, Vesa Kataja, Jaana Hartikainen, Nicholas E Day, David R Cox, Bruce AJ Ponder
Publication date
2007/6/28
Journal
Nature
Volume
447
Issue
7148
Pages
1087-1093
Publisher
Nature Publishing Group UK
Description
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast cancer, and the residual genetic variance is likely to be due to variants conferring more moderate risks. To identify further susceptibility alleles, we conducted a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls, followed by a third stage in which 30 single nucleotide polymorphisms (SNPs) were tested for confirmation in 21,860 cases and 22,578 controls from 22 studies. We used 227,876 SNPs that were estimated to correlate with 77% of known common SNPs in Europeans at r2 > 0.5. SNPs in five novel independent loci exhibited strong and consistent evidence of association with breast cancer (P < 10-7). Four of these contain plausible causative genes (FGFR2, TNRC9, MAP3K1 …
Total citations
Scholar articles
DF Easton, KA Pooley, AM Dunning, PDP Pharoah… - Nature, 2007