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832 THE RNA-BINDING PROTEIN TRISTETRAPROLIN CONTROLS INTESTINAL CELL DIFFERENTIATION AND BACTERIAL SYMBIOSIS THROUGH THE NOTCH SIGNALING PATHWAY Vikalp Vishwakarma, Sandhya Sanduja, Shufei Zhuang, Ranjan Preet, Dan A. Dixon The Notch signaling pathway controls epithelial cell fate during intestinal differentiation through activating Hes1 and Atoh1/Math1 transcription factors. In colorectal cancer (CRC), constitutive Notch activation allows enhanced Hes1 expression associated with absorptive cell-differentiation and tumor progression; however, mechanism for constitutive Notch activation in CRC is not known. Here, we investigated the regulation of Notch signaling and its effect on intestinal cell differentiation and microbiota by the mRNA decay factor Tristetraprolin (TTP) in CRC and TTP-knockout mice. TTP controls pro-inflammatory and oncogenic gene expression in …