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Numerous methods are available for suppression of the HZ0 resonance in the ‘H NMR spectra of water-soluble compounds (1). On average, these methods present a trade-off between the excitation profile and the level of suppression of the water resonance: with few exceptions, methods that yield the best solvent suppression per single scan tend to have a worse excitation profile than the simple “jump-and-return” or “1-1” sequence (2) which has a relatively good, sine-bell-shaped excitation profile. For H20 suppression in 2D experiments, a second and even more important criterion is the reproducibility of HZ0 suppression from one scan to the next. Poor reproducibility leads to t, noise in the vicinity of the HZ0 F2 frequency and the tails of this unsuppressed HZ0 resonance can extend into the spectral region of interest. Here we demonstrate that treatment of the time-domain data is an effective method for removing …