Authors
Heather Cody Hazlett, Hongbin Gu, Brent C Munsell, Sun Hyung Kim, Martin Styner, Jason J Wolff, Jed T Elison, Meghan R Swanson, Hongtu Zhu, Kelly N Botteron, D Louis Collins, John N Constantino, Stephen R Dager, Annette M Estes, Alan C Evans, Vladimir S Fonov, Guido Gerig, Penelope Kostopoulos, Robert C McKinstry, Juhi Pandey, Sarah Paterson, John R Pruett, Robert T Schultz, Dennis W Shaw, Lonnie Zwaigenbaum, Joseph Piven, IBIS Network Clinical Sites Piven J. 17 Hazlett HC 17 Chappell C. 17 Dager SR 18 Estes AM 18 Shaw DW 18 Botteron KN 19 McKinstry RC 19 Constantino JN 19 Pruett Jr JR 19 Schultz RT 20 Paterson S. 20 Zwaigenbaum L. 21 Elison JT 22 Wolff JJ 22, Data Coordinating Center Evans AC 23 Collins DL 23 Pike GB 23 Fonov VS 23 Kostopoulos P. 23 Das S. 23, Image Processing Core Gerig G. 24 Styner M. 17, Statistical Analysis Gu Core H. 17
Publication date
2017/2/16
Journal
Nature
Volume
542
Issue
7641
Pages
348-351
Publisher
Nature Publishing Group UK
Description
Brain enlargement has been observed in children with autism spectrum disorder (ASD), but the timing of this phenomenon, and the relationship between ASD and the appearance of behavioural symptoms, are unknown. Retrospective head circumference and longitudinal brain volume studies of two-year olds followed up at four years of age have provided evidence that increased brain volume may emerge early in development,. Studies of infants at high familial risk of autism can provide insight into the early development of autism and have shown that characteristic social deficits in ASD emerge during the latter part of the first and in the second year of life,. These observations suggest that prospective brain-imaging studies of infants at high familial risk of ASD might identify early postnatal changes in brain volume that occur before an ASD diagnosis. In this prospective neuroimaging study of 106 infants at high …
Scholar articles
HC Hazlett, H Gu, BC Munsell, SH Kim, M Styner… - Nature, 2017