Authors
Carolina Lucas, Jon Klein, Maria E Sundaram, Feimei Liu, Patrick Wong, Julio Silva, Tianyang Mao, Ji Eun Oh, Subhasis Mohanty, Jiefang Huang, Maria Tokuyama, Peiwen Lu, Arvind Venkataraman, Annsea Park, Benjamin Israelow, Chantal BF Vogels, M Catherine Muenker, C-Hong Chang, Arnau Casanovas-Massana, Adam J Moore, Joseph Zell, John B Fournier, Anne L Wyllie, Melissa Campbell, Alfred I Lee, Hyung J Chun, Nathan D Grubaugh, Wade L Schulz, Shelli Farhadian, Charles Dela Cruz, Aaron M Ring, Albert C Shaw, Adam V Wisnewski, Inci Yildirim, Albert I Ko, Saad B Omer, Akiko Iwasaki
Publication date
2021/7
Journal
Nature medicine
Volume
27
Issue
7
Pages
1178-1186
Publisher
Nature Publishing Group US
Description
Recent studies have provided insights into innate and adaptive immune dynamics in coronavirus disease 2019 (COVID-19). However, the exact features of antibody responses that govern COVID-19 disease outcomes remain unclear. In this study, we analyzed humoral immune responses in 229 patients with asymptomatic, mild, moderate and severe COVID-19 over time to probe the nature of antibody responses in disease severity and mortality. We observed a correlation between anti-spike (S) immunoglobulin G (IgG) levels, length of hospitalization and clinical parameters associated with worse clinical progression. Although high anti-S IgG levels correlated with worse disease severity, such correlation was time dependent. Deceased patients did not have higher overall humoral response than discharged patients. However, they mounted a robust, yet delayed, response, measured by anti-S, anti-receptor-binding …
Scholar articles
C Lucas, J Klein, ME Sundaram, F Liu, P Wong, J Silva… - Nature medicine, 2021
C Lucas, J Klein, ME Sundaram, F Liu, P Wong, J Silva… - Nature Medicine, 2021