Authors
Julio Silva, Carolina Lucas, Maria Sundaram, Benjamin Israelow, Patrick Wong, Jon Klein, Maria Tokuyama, Peiwen Lu, Arvind Venkataraman, Feimei Liu, Tianyang Mao, Ji Eun Oh, Annsea Park, Arnau Casanovas-Massana, Chantal BF Vogels, M Catherine Muenker, Joseph Zell, John B Fournier, Melissa Campbell, Michael Chiorazzi, Edwin Ruiz Fuentes, Mary E Petrone, Chaney C Kalinich, Isabel M Ott, Annie Watkins, Adam J Moore, Maura Nakahata, Shelli Farhadian, Charles Dela Cruz, Albert I Ko, Wade L Schulz, Aaron Ring, Shuangge Ma, Saad Omer, Anne L Wyllie, Akiko Iwasaki, Yale IMPACT Team
Publication date
2021/1/10
Journal
MedRxiv
Publisher
Cold Spring Harbor Laboratory Preprints
Description
While several clinical and immunological parameters correlate with disease severity and mortality in SARS-CoV-2 infection, work remains in identifying unifying correlates of coronavirus disease 2019 (COVID-19) that can be used to guide clinical practice. Here, we examine saliva and nasopharyngeal (NP) viral load over time and correlate them with patient demographics, and cellular and immune profiling. We found that saliva viral load was significantly higher in those with COVID-19 risk factors; that it correlated with increasing levels of disease severity and showed a superior ability over nasopharyngeal viral load as a predictor of mortality over time (AUC= 0.90). A comprehensive analysis of immune factors and cell subsets revealed strong predictors of high and low saliva viral load, which were associated with increased disease severity or better overall outcomes, respectively. Saliva viral load was positively …
Total citations
Scholar articles
J Silva, C Lucas, M Sundaram, B Israelow, P Wong… - MedRxiv, 2021