Authors
Michael A Flierl, Daniel Rittirsch, Brian A Nadeau, Anthony J Chen, J Vidya Sarma, Firas S Zetoune, Stephanie R McGuire, Rachel P List, Danielle E Day, L Marco Hoesel, Hongwei Gao, Nico Van Rooijen, Markus S Huber-Lang, Richard R Neubig, Peter A Ward
Publication date
2007/10
Journal
Nature
Volume
449
Issue
7163
Pages
721-725
Publisher
Nature Publishing Group
Description
It is becoming increasingly clear that the autonomic nervous system and the immune system demonstrate cross-talk during inflammation by means of sympathetic and parasympathetic pathways,. We investigated whether phagocytes are capable of de novo production of catecholamines, suggesting an autocrine/paracrine self-regulatory mechanism by catecholamines during inflammation, as has been described for lymphocytes. Here we show that exposure of phagocytes to lipopolysaccharide led to a release of catecholamines and an induction of catecholamine-generating and degrading enzymes, indicating the presence of the complete intracellular machinery for the generation, release and inactivation of catecholamines. To assess the importance of these findings in vivo, we chose two models of acute lung injury. Blockade of α2-adrenoreceptors or catecholamine-generating enzymes greatly suppressed lung …
Total citations
Scholar articles
MA Flierl, D Rittirsch, BA Nadeau, AJ Chen, JV Sarma… - Nature, 2007