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We introduce INCEpTION, a new annotation platform for tasks including interactive and semantic annotation (eg, concept linking, fact linking, knowledge base population, semantic frame annotation). These tasks are very time consuming and demanding for annotators, especially when knowledge bases are used. We address these issues by developing an annotation platform that incorporates machine learning capabilities which actively assist and guide annotators. The platform is both generic and modular. It targets a range of research domains in need of semantic annotation, such as digital humanities, bioinformatics, or linguistics. INCEpTION is publicly available as open-source software.