Authors
Hui Zhang, Tao Liu, Zhen Zhang, Samuel H Payne, Bai Zhang, Jason E McDermott, Jian-Ying Zhou, Vladislav A Petyuk, Li Chen, Debjit Ray, Shisheng Sun, Feng Yang, Lijun Chen, Jing Wang, Punit Shah, Seong Won Cha, Paul Aiyetan, Sunghee Woo, Yuan Tian, Marina A Gritsenko, Therese R Clauss, Caitlin Choi, Matthew E Monroe, Stefani Thomas, Song Nie, Chaochao Wu, Ronald J Moore, Kun-Hsing Yu, David L Tabb, David Fenyö, Vineet Bafna, Yue Wang, Henry Rodriguez, Emily S Boja, Tara Hiltke, Robert C Rivers, Lori Sokoll, Heng Zhu, Ie-Ming Shih, Leslie Cope, Akhilesh Pandey, Bing Zhang, Michael P Snyder, Douglas A Levine, Richard D Smith, Daniel W Chan, Karin D Rodland, Steven A Carr, Michael A Gillette, Karl R Klauser, Eric Kuhn, DR Mani, Philipp Mertins, Karen A Ketchum, Ratna Thangudu, Shuang Cai, Mauricio Oberti, Amanda G Paulovich, Jeffrey R Whiteaker, Nathan J Edwards, Peter B McGarvey, Subha Madhavan, Pei Wang, Gordon A Whiteley, Steven J Skates, Forest M White, Christopher R Kinsinger, Mehdi Mesri, Kenna M Shaw, Stephen E Stein, David Fenyo, Paul Rudnick, Michael Snyder, Yingming Zhao, Xian Chen, David F Ransohoff, Andrew N Hoofnagle, Daniel C Liebler, Melinda E Sanders, Zhiao Shi, Robbert JC Slebos, Lisa J Zimmerman, Sherri R Davies, Li Ding, Matthew JC Ellis, R Reid Townsend
Publication date
2016/7/28
Journal
Cell
Volume
166
Issue
3
Pages
755-765
Publisher
Cell Press
Description
To provide a detailed analysis of the molecular components and underlying mechanisms associated with ovarian cancer, we performed a comprehensive mass-spectrometry-based proteomic characterization of 174 ovarian tumors previously analyzed by The Cancer Genome Atlas (TCGA), of which 169 were high-grade serous carcinomas (HGSCs). Integrating our proteomic measurements with the genomic data yielded a number of insights into disease, such as how different copy-number alternations influence the proteome, the proteins associated with chromosomal instability, the sets of signaling pathways that diverse genome rearrangements converge on, and the ones most associated with short overall survival. Specific protein acetylations associated with homologous recombination deficiency suggest a potential means for stratifying patients for therapy. In addition to providing a valuable resource, these …
Scholar articles
H Zhang, T Liu, Z Zhang, SH Payne, B Zhang… - Cell, 2016