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Pressures on infrastructure—due to growing urban populations, the ubiquity of new technologies, and collaborative business models—are fostering a new form of entrepreneurship focused on addressing quality of life in cities. Urban entrepreneurs are challenging the logic of formal market structures, forcing us to re-frame our thinking around the interactions between place, individuals, institutions, and the resulting innovative outcomes. Urban entrepreneurs—operating at the neighborhood, city, and global levels—are developing alternative forms of private-public-people partnerships and unique business strategies.