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This paper presents computer-based analysis and design of control systems for centrifugal compressors when the operating fluid is supercritical CO₂. It demonstrates that the design of the control system of the compressor must take into account the state of the fluid. It also evaluates if the plant configuration allows compressor operation within a given surge margin. The results show the impact of the operating conditions of the compression station on surge prevention, their effect on the energy consumption, and suggest ways of dealing with supercritical fluid while controlling a compressor.