Authors
Fabio Pesciaioli, Uttam Dhawa, João CA Oliveira, Rongxin Yin, Michael John, Lutz Ackermann
Publication date
2018/11/19
Journal
Angewandte Chemie International Edition
Volume
57
Issue
47
Pages
15425-15429
Description
The enantioselective cobalt(III)‐catalyzed C−H alkylation was achieved through the design of a novel chiral acid. The cobalt(III)‐catalyzed enantioselective C−H activation was characterized by high position‐, regio‐ and enantio‐control under exceedingly mild reaction conditions. Thereby, the robust cooperative cobalt(III) catalysis proved tolerant of valuable electrophilic functional groups, including hydroxyl, bromo, and iodo substituents. Mechanistic studies revealed a considerable additive effect on kinetics and on a negative non‐linear‐effect.
Scholar articles
F Pesciaioli, U Dhawa, JCA Oliveira, R Yin, M John… - Angewandte Chemie International Edition, 2018