Authors
Sara Duce, Fabio Pesciaioli, Lucia Gramigna, Luca Bernardi, Andrea Mazzanti, Alfredo Ricci, Giuseppe Bartoli, Giorgio Bencivenni
Publication date
2011/4/18
Journal
Advanced Synthesis & Catalysis
Volume
353
Issue
6
Pages
860-864
Publisher
WILEY‐VCH Verlag
Description
The first catalytic asymmetric Pictet–Spengler reaction of isatins is presented. BINOL‐derived phosphoric acids were found to be competent catalysts for this transformation, giving challenging spirooxindole structures bearing a quaternary stereocentre with generally good results. The 1,2,3,4‐tetrahydro‐β‐carboline products (spiroindolinones) are the core of some newly discovered anti‐malarial agents.
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Scholar articles
S Duce, F Pesciaioli, L Gramigna, L Bernardi… - Advanced Synthesis & Catalysis, 2011