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Identification of virus sources is one of the most important activities to control the spread of epidemics. Virus sources can be identified using an inverse optimization model. The inverse optimization model minimizes the error between simulated and observed concentrations at observation locations of the aquifer. The observed concentration can be obtained from field observation of contaminants. The simulated concentration can be obtained through the flow and virus transport simulation models. As such, the flow and transport simulation models need to be incorporated into the optimization model. As a result, the complexity of the problem is related to the dimension of the simulation models. For reducing the computational burden, generally, one- or two-dimensional simulation model is considered in finding the virus sources. However, to mimic the real world situation, one has to use the three-dimensional (3D) virus …