Authors
Gita A Pathak, Renato Polimanti, Juha Karjalainen, Mark Daly, Andrea Ganna, Mark J Daly, Christine Stevens, Masahiro Kanai, Rachel G Liao, Amy Trankiem, Mary K Balaconis, Huy Nguyen, Matthew Solomonson, Kumar Veerapen, Samuli Ripatti, Lindo Nkambul, Sam Bryant, Vijay G Sankaran, Benjamin M Neale, Konrad J Karczewski, Alicia R Martin, Elizabeth G Atkinson, Kristin Tsuo, Nikolas Baya, Patrick Turley, Rahul Gupta, Raymond K Walters, Duncan S Palmer, Gopal Sarma, Nathan Cheng, Wenhan Lu, Claire Churchhouse, Jacqueline Goldstein, Daniel King, Wei Zhou, Cotton Seed, Hilary Finucane, F Kyle Satterstrom, Shea J Andrews, Laura G Sloofman, Stuart C Sealfon, Clive Hoggart, Slayton J Underwood, Mattia Cordioli, Matti Pirinen, Kati Donner, Katja Kivinen, Aarno Palotie, Mari Kaunisto, Nadia Harerimana, Karolina Chwialkowska, Brooke Wolford, Genevieve Roberts, Danny Park, Catherine A Ball, Marie Coignet, Shannon McCurdy, Spencer Knight, Raghavendran Partha, Brooke Rhead, Miao Zhang, Nathan Berkowitz, Michael Gaddis, Keith Noto, Luong Ruiz, Milos Pavlovic, Eurie L Hong, Kristin Rand, Ahna Girshick, Harendra Guturu, Asher Haug Baltzell, Mari EK Niemi, Sara Pigazzini, Souad Rahmouni, Michel Georges, Yasmine Belhaj, Julien Guntz, Sabine Claassen, Yves Beguin, Stephanie Gofflot, Lindokuhle Nkambule, Lindokuhle Nkambul, Caroline Cusick, Michel Moutschen, Benoit Misset, Gilles Darcis, Julien Guiot, Samira Azarzar, Olivier Malaise, Pascale Huynen, Christelle Meuris, Marie Thys, Jessica Jacques, Philippe Leonard, Frederic Frippiat, Jean-Baptiste Giot, Anne-Sophie Sauvage, Christian Von Frenckell, Bernard Lambermont, Tomoko Nakanishi, David R Morrison, J Brent Richards, Guillaume Butler-Laporte, Vincenzo Forgetta, Biswarup Ghosh, Laetitia Laurent, Danielle Henry, Tala Abdullah, Olumide Adeleye, Noor Mamlouk, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, Branka Vulesevic, Meriem Bouab, Charlotte Guzman, Louis Petitjean, Chris Tselios, Xiaoqing Xue, Jonathan Afilalo, Darin Adra, Vincent Mooser, Rui Li, Alexandre Belisle, Pierre Lepage, Jiannis Ragoussis, Daniel Auld, G Mark Lathrop, Marc Afilalo, Maureen Oliveira, Bluma Brenner, Nathalie Brassard, Madeleine Durand, Michael Chasse, Daniel E Kaufmann, Erwin Schurr, Caroline Hayward, Anne Richmond, J Kenneth Baillie, Joseph T Glessner, Hakon Hakonarson, Xiao Chang, Douglas M Shaw, Jennifer Below, Hannah Polikowski, Petty E Lauren, Hung-Hsin Chen, Wanying Zhu, Lea Davis, V Eric Kerchberger
Publication date
2022/8/3
Publisher
University of Leicester
Description
The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity.
Scholar articles
GA Pathak, R Polimanti, J Karjalainen, M Daly… - 2022