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This article describes the fabrication, characterization, and real-life application of a soft, stretchable electronic-skin-based biofuel cell (E-BFC) that exhibits an open circuit voltage of 0.5 V and a power density of nearly 1.2 mW cm−2 at 0.2 V, representing the highest power density recorded by a wearable biofuel cell to date. High power density is achieved via a unique combination of lithographically-patterned stretchable electronic framework together with screen-printed, densely-packed three-dimensional carbon-nanotube-based bioanode and cathode array arranged in a stretchable “island-bridge” configuration. The E-BFC maintains its performance even under repeated strains of 50%, and is stable for two days. When applied directly to the skin of human subjects, the E-BFC generates ∼1 mW during exercise. The E-BFC is able to power conventional electronic devices, such as a light emitting diode and a …