Authors
LM Biehl, A Huth, J Panse, C Krämer, M Hentrich, M Engelhardt, Kerstin Schäfer-Eckart, G Kofla, M Kiehl, C-M Wendtner, M Karthaus, AJ Ullmann, M Hellmich, H Christ, MJGT Vehreschild
Publication date
2016/10/1
Journal
Annals of Oncology
Volume
27
Issue
10
Pages
1916-1922
Publisher
Elsevier
Description
Background
Central venous catheter (CVC)-related bloodstream infections (CRBSI) are a frequent cause of morbidity and mortality in patients with chemotherapy-induced neutropenia. Chlorhexidine containing catheter securement dressings may prevent CRBSI.
Patients and methods
A multicenter randomized, controlled trial was conducted at 10 German hematology departments. We compared chlorhexidine-containing dressings with non-chlorhexidine control dressings in neutropenic patients. The primary end point was the incidence of definite CRBSI within the first 14 days (dCRBSI14) of CVC placement. Secondary end points included combined incidence of definite or probable CRBSI within 14 days (dpCRBSI14), overall (dpCRBSI), incidence of unscheduled dressing changes and adverse events.
Results
From February 2012 to September 2014, 613 assessable patients were included in the study. The …
Scholar articles
LM Biehl, A Huth, J Panse, C Krämer, M Hentrich… - Annals of Oncology, 2016