Authors
Vishwanath R Iyer, Michael B Eisen, Douglas T Ross, Greg Schuler, Troy Moore, Jeffrey CF Lee, Jeffrey M Trent, Louis M Staudt, James Hudson Jr, Mark S Boguski, Deval Lashkari, Dari Shalon, David Botstein, Patrick O Brown
Publication date
1999/1/1
Journal
science
Volume
283
Issue
5398
Pages
83-87
Publisher
American Association for the Advancement of Science
Description
The temporal program of gene expression during a model physiological response of human cells, the response of fibroblasts to serum, was explored with a complementary DNA microarray representing about 8600 different human genes. Genes could be clustered into groups on the basis of their temporal patterns of expression in this program. Many features of the transcriptional program appeared to be related to the physiology of wound repair, suggesting that fibroblasts play a larger and richer role in this complex multicellular response than had previously been appreciated.
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Scholar articles
VR Iyer, MB Eisen, DT Ross, G Schuler, T Moore… - science, 1999