Authors
Rik P Bogers, Wanda JE Bemelmans, Rudolf T Hoogenveen, Hendriek C Boshuizen, Mark Woodward, Paul Knekt, Rob M Van Dam, Frank B Hu, Tommy LS Visscher, Alessandro Menotti, Roland J Thorpe, Konrad Jamrozik, Susanna Calling, Bjørn Heine Strand, Martin J Shipley, BMI-CHD Collaboration Investigators
Publication date
2007/9/10
Source
Archives of internal medicine
Volume
167
Issue
16
Pages
1720-1728
Publisher
American Medical Association
Description
Background
The extent to which moderate overweight (body mass index [BMI], 25.0-29.9 [calculated as weight in kilograms divided by height in meters squared]) and obesity (BMI, ≥ 30.0) are associated with increased risk of coronary heart disease (CHD) through adverse effects on blood pressure and cholesterol levels is unclear, as is the risk of CHD that remains after these mediating effects are considered.
Methods
Relative risks (RRs) of CHD associated with moderate overweight and obesity with and without adjustment for blood pressure and cholesterol concentrations were calculated by the members of a collaboration of prospective cohort studies of healthy, mainly white persons and pooled by means of random-effects models (RRs for categories of BMI in 14 cohorts and for continuous BMI in 21 cohorts; total N = 302 296).
Results
A total of 18 000 CHD events occurred during follow-up. The age-, sex-, physical …
Total citations
Scholar articles
RP Bogers, WJE Bemelmans, RT Hoogenveen… - Archives of internal medicine, 2007