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OBJECTIVE—To systematically evaluate the evidence for an association between physical activity of moderate intensity and risk of type 2 diabetes.

RESEARCH DESIGN AND METHODS—We searched EMBASE and Medline through March 2006 and examined reference lists of retrieved articles. We excluded studies that did not assess physical activity of moderate intensity independent of activities of vigorous intensity (more than six times the resting metabolic rate). Information on study design, participant characteristics, assessment of physical activity, and outcomes and estimates of associations were extracted independently by two investigators. We calculated summary relative risks (RRs) using a random-effects model for the highest versus the lowest reported duration of activities.

RESULTS—We identified 10 prospective cohort studies of physical activity of moderate intensity and type …