Authors
Chang-Fu Kuo, Matthew J Grainge, Ana M Valdes, Lai-Chu See, Shue-Fen Luo, Kuang-Hui Yu, Weiya Zhang, Michael Doherty
Publication date
2015/9/1
Journal
JAMA internal medicine
Volume
175
Issue
9
Pages
1518-1526
Publisher
American Medical Association
Description
Importance
Relatives of patients with systemic lupus erythematosus (SLE) appear to be at higher risk of SLE and other autoimmune diseases, but estimates of individual familial risks are largely unavailable or unreliable. Furthermore, relative contributions of genetic, shared, and unshared environmental factors to SLE susceptibility remain unclear.
Objective
To examine familial aggregation and heritability of SLE and the relative risks (RRs) of other autoimmune diseases in relatives of patients with SLE.
Design, Setting, and Participants
A population-based family study using the Taiwan National Health Insurance Research Database was conducted. Participants included all individuals (N = 23 658 577) registered with that database in 2010; of these, 18 283 had SLE. We identified 21 009 551 parent-child relationships, 17 168 340 full sibling pairs, and 342 066 twin pairs. Diagnoses of SLE were ascertained …
Scholar articles
CF Kuo, MJ Grainge, AM Valdes, LC See, SF Luo… - JAMA internal medicine, 2015