Authors
Katharina Domschke, Andreas Reif, Heike Weber, Jan Richter, Christa Hohoff, Patricia Ohrmann, Anya Pedersen, Jochen Bauer, Thomas Suslow, Harald Kugel, Walter Heindel, Christian Baumann, Benedikt Klauke, Christian Jacob, Wolfgang Maier, Jürgen Fritze, Borwin Bandelow, Petra Krakowitzky, Matthias Rothermundt, Angelika Erhardt, Elisabeth B Binder, Florian Holsboer, Alexander L Gerlach, Tilo Kircher, Thomas Lang, Georg W Alpers, Andreas Ströhle, Lydia Fehm, Andrew T Gloster, Hans-Ulrich Wittchen, Volker Arolt, Paul Pauli, Alfons Hamm, Jürgen Deckert
Publication date
2011/9
Journal
Molecular psychiatry
Volume
16
Issue
9
Pages
938-948
Publisher
Nature Publishing Group
Description
Animal studies have suggested neuropeptide S (NPS) and its receptor (NPSR) to be involved in the pathogenesis of anxiety-related behavior. In this study, a multilevel approach was applied to further elucidate the role of NPS in the etiology of human anxiety. The functional NPSR A/T (Asn 107 Ile) variant (rs324981) was investigated for association with (1) panic disorder with and without agoraphobia in two large, independent case–control studies,(2) dimensional anxiety traits,(3) autonomic arousal level during a behavioral avoidance test and (4) brain activation correlates of anxiety-related emotional processing in panic disorder. The more active NPSR rs324981 T allele was found to be associated with panic disorder in the female subgroup of patients in both samples as well as in a meta-analytic approach. The T risk allele was further related to elevated anxiety sensitivity, increased heart rate and higher symptom …
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Scholar articles
K Domschke, A Reif, H Weber, J Richter, C Hohoff… - Molecular psychiatry, 2011