Authors
Edgar R Miller III, Roberto Pastor-Barriuso, Darshan Dalal, Rudolph A Riemersma, Lawrence J Appel, Eliseo Guallar
Publication date
2005/1/4
Source
Annals of internal medicine
Volume
142
Issue
1
Pages
37-46
Publisher
American College of Physicians
Description
Background
Experimental models and observational studies suggest that vitamin E supplementation may prevent cardiovascular disease and cancer. However, several trials of high-dosage vitamin E supplementation showed non–statistically significant increases in total mortality.
Purpose
To perform a meta-analysis of the dose–response relationship between vitamin E supplementation and total mortality by using data from randomized, controlled trials.
Patients
135 967 participants in 19 clinical trials. Of these trials, 9 tested vitamin E alone and 10 tested vitamin E combined with other vitamins or minerals. The dosages of vitamin E ranged from 16.5 to 2000 IU/d (median, 400 IU/d).
Data Sources
PubMed search from 1966 through August 2004, complemented by a search of the Cochrane Clinical Trials …
Total citations
Scholar articles
ER Miller III, R Pastor-Barriuso, D Dalal… - Annals of internal medicine, 2005