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Breast cancer disease is considered to be the second leading reason for death among women. Unfortunately, even if the treatment of cancer started soon after diagnosis, the cancer cells may remain in the body, and cancer may recur. Various Machine Learning (ML) methods to predict breast cancer recurrence were applied recently, and the ML methods’ performance needs to be examined to determine the proper method for prediction. Usually, the datasets contain many features which may sometimes mislead the prediction process; as some features may lead to confusion or inaccurate prediction. Thus, in this study, two breast cancer recurrence datasets were statistically analyzed and further refined by Brain Storming Optimization algorithm (BSO). The proposed multi-stages technique consists of three main stages; first, the statistical feature selection methods (SFM) which statistically select the discriminative …