Authors
Yue Ran Sun, Nathan Herrmann, Christopher JM Scott, Sandra E Black, Maisha M Khan, Krista L Lanctôt
Publication date
2018/1/1
Source
Journal of affective disorders
Volume
225
Pages
599-606
Publisher
Elsevier
Description
Objective
The goal of this meta-analysis was to quantitatively summarize the evidence available on the differences in grey matter volume between lithium-treated and lithium-free bipolar patients.
Methods
A systematic search was conducted in Cochrane Central, Embase, MEDLINE, and PsycINFO databases for original peer-reviewed journal articles that reported on global grey matter volume in lithium-medicated and lithium-free bipolar patients. Standard mean difference and Hedges’ g were used to calculate effect size in a random-effects model. Risk of publication bias was assessed using Egger's test and quality of evidence was assessed using standard criteria.
Results
There were 15 studies with a total of 854 patients (368 lithium-medicated, 486 lithium-free) included in the meta-analysis. Global grey matter volume was significantly larger in lithium-treated bipolar patients compared to lithium-free patients (SMD: 0 …
Scholar articles
YR Sun, N Herrmann, CJM Scott, SE Black, MM Khan… - Journal of affective disorders, 2018