Authors
Walter Swardfager, Di Yu, Joel Ramirez, Hugo Cogo‐Moreira, Gregory Szilagyi, Melissa F Holmes, Christopher JM Scott, Gustavo Scola, Pak C Chan, Jialun Chen, Parco Chan, Demetrios J Sahlas, Nathan Herrmann, Krista L Lanctôt, Ana C Andreazza, Jacqueline A Pettersen, Sandra E Black
Publication date
2017
Journal
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Volume
7
Issue
1
Pages
56-60
Description
Introduction
White matter hyperintensities (WMH) presumed to reflect cerebral small vessel disease and increased peripheral inflammatory markers are found commonly in Alzheimer's disease (AD), but their interrelationships remain unclear.
Methods
Inflammatory markers were assayed in 54 elderly participants (n = 16 with AD). Periventricular WMH were delineated from T1, T2/proton density, and fluid‐attenuated magnetic resonance imaging using semiautomated fuzzy lesion extraction and coregistered with maps of fractional anisotropy (FA), a measure of microstructural integrity assessed using diffusion tensor imaging.
Results
Mean FA within periventricular WMH was associated with an inflammatory factor consisting of interleukin (IL)‐1β, tumor necrosis factor, IL‐10, IL‐21, and IL‐23 in patients with AD (ρ = −0.703, P = .002) but not in healthy elderly (ρ = 0.217, P = .190). Inflammation was associated with …
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