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This paper outlines a framework for an info-symbiotic modelling system using cyber-physical sensors to assist in decision-making. Using a dynamic data-driven simulation approach, this system can help with the identification of target areas and resource allocation in emergency situations. Using different natural disasters as exemplars, we will show how cyber-physical sensors can enhance ground level intelligence and aid in the creation of dynamic models to capture the state of human casualties. Using a virtual command & control centre communicating with sensors in the field, up-to-date information of the ground realities can be incorporated in a dynamic feedback loop. Using other information (e.g. Weather models) a complex and rich model can be created. The framework adaptively manages the heterogeneous collection of data resources and uses agent-based models to create what-if scenarios in order to …