Authors
Benjamin Lanfer, Michael Scherg, Moritz Dannhauer, Thomas R Knösche, Martin Burger, Carsten H Wolters
Publication date
2012/8/1
Journal
NeuroImage
Volume
62
Issue
1
Pages
418-431
Publisher
Academic Press
Description
The low-conducting human skull is known to have an especially large influence on electroencephalography (EEG) source analysis. Because of difficulties segmenting the complex skull geometry out of magnetic resonance images, volume conductor models for EEG source analysis might contain inaccuracies and simplifications regarding the geometry of the skull. The computer simulation study presented here investigated the influences of a variety of skull geometry deficiencies on EEG forward simulations and source reconstruction from EEG data. Reference EEG data was simulated in a detailed and anatomically plausible reference model. Test models were derived from the reference model representing a variety of skull geometry inaccuracies and simplifications. These included erroneous skull holes, local errors in skull thickness, modeling cavities as bone, downward extension of the model and simplifying the …
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