Authors
Marcelo Cypel, Mingyao Liu, Matt Rubacha, Jonathan C Yeung, Shin Hirayama, Masaki Anraku, Masaaki Sato, Jeffrey Medin, Beverly L Davidson, Marc de Perrot, Thomas K Waddell, Arthur S Slutsky, Shaf Keshavjee
Publication date
2009/10/28
Journal
Science translational medicine
Volume
1
Issue
4
Pages
4ra9-4ra9
Publisher
American Association for the Advancement of Science
Description
More than 80% of potential donor lungs are injured during brain death of the donor and from complications experienced in the intensive care unit, and therefore cannot be used for transplantation. These lungs show inflammation and disruption of the alveolar-capillary barrier, leading to poor gas exchange. Although the number of patients in need of lung transplantation is increasing, the number of donors is static. We investigated the potential to use gene therapy with an adenoviral vector encoding human interleukin-10 (AdhIL-10) to repair injured donor lungs ex vivo before transplantation. IL-10 is an anti-inflammatory cytokine that mainly exerts its suppressive functions by the inactivation of antigen-presenting cells with consequent inhibition of proinflammatory cytokine secretion. In pigs, AdhIL-10–treated lungs exhibited attenuated inflammation and improved function after transplantation. Lungs from 10 human …
Total citations
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Scholar articles
M Cypel, M Liu, M Rubacha, JC Yeung, S Hirayama… - Science translational medicine, 2009