Authors
Tine Verreet, Roel Quintens, Debby Van Dam, Mieke Verslegers, Mirella Tanori, Arianna Casciati, Mieke Neefs, Liselotte Leysen, Arlette Michaux, Ann Janssen, Emiliano D'Agostino, Greetje Vande Velde, Sarah Baatout, Lieve Moons, Simonetta Pazzaglia, Anna Saran, Uwe Himmelreich, Peter Paul De Deyn, Mohammed Abderrafi Benotmane
Publication date
2015/1/9
Journal
Journal of Neurodevelopmental Disorders
Volume
7
Issue
3
Description
Background
In humans, in utero exposure to ionising radiation results in an increased prevalence of neurological aberrations, such as small head size, mental retardation and decreased IQ levels. Yet, the association between early damaging events and long-term neuronal anomalies remains largely elusive.
Methods
Mice were exposed to different X-ray doses, ranging between 0.0 and 1.0 Gy, at embryonic days (E) 10, 11 or 12 and subjected to behavioural tests at 12 weeks of age. Underlying mechanisms of irradiation at E11 were further unravelled using magnetic resonance imaging (MRI) and spectroscopy, diffusion tensor imaging, gene expression profiling, histology and immunohistochemistry.
Results
Irradiation at the onset of neurogenesis elicited behavioural changes in young adult mice, dependent on the …
Scholar articles
T Verreet, R Quintens, D Van Dam, M Verslegers… - Journal of neurodevelopmental disorders, 2015