Authors
Simon Feys, Samuel M Gonçalves, Mona Khan, Sumin Choi, Bram Boeckx, Denis Chatelain, Cristina Cunha, Yves Debaveye, Greet Hermans, Marjan Hertoghs, Stephanie Humblet-Baron, Cato Jacobs, Katrien Lagrou, Lukas Marcelis, Julien Maizel, Philippe Meersseman, Rémy Nyga, Laura Seldeslachts, Marick Rodrigues Starick, Karin Thevissen, Christophe Vandenbriele, Lore Vanderbeke, Greetje Vande Velde, Niels Van Regenmortel, Arno Vanstapel, Sam Vanmassenhove, Alexander Wilmer, Frank L Van De Veerdonk, Gert De Hertogh, Peter Mombaerts, Diether Lambrechts, Agostinho Carvalho, Johan Van Weyenbergh, Joost Wauters
Publication date
2022/12/1
Journal
The Lancet Respiratory Medicine
Volume
10
Issue
12
Pages
1147-1159
Publisher
Elsevier
Description
Background
Influenza-associated pulmonary aspergillosis (IAPA) and COVID-19-associated pulmonary aspergillosis (CAPA) affect about 15% of critically ill patients with influenza or COVID-19, respectively. These viral–fungal coinfections are difficult to diagnose and are associated with increased mortality, but data on their pathophysiology are scarce. We aimed to explore the role of lung epithelial and myeloid innate immunity in patients with IAPA or CAPA.
Methods
In this observational study, we retrospectively recruited patients who had been admitted to the intensive care unit (ICU) of University Hospitals Leuven, Belgium, requiring non-invasive or invasive ventilation because of severe influenza or COVID-19, with or without aspergillosis, between Jan 1, 2011, and March 31, 2021, whose bronchoalveolar lavage samples were available at the hospital biobank. Additionally, biobanked in vivo tracheobronchial …
Total citations
Scholar articles
S Feys, SM Gonçalves, M Khan, S Choi, B Boeckx… - The Lancet Respiratory Medicine, 2022