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Dear Sir, Platelet proteomics is a young field that took off at the beginning of this century and soon yielded relevant results. The basic concept for platelet proteomic researchers is that, because platelets do not have a nucleus, proteomics is an ideal tool to approach their biochemistry. This concept proved to be true and thus, during the last ten years proteomics allowed the discovery of new platelet receptors and signaling proteins, some of which were shown to play a significant role in platelet activation. Indeed, some of these proteins are being studied as potential anti-thrombotic drug targets1. The initial success was taken with cautious optimism by platelet researchers, some of whom took the challenge of applying platelet proteomics to more clinical orientated studies. The aim was to take advantage of the technology in a clinical environment in order to find novel biomarkers and drug targets for those pathologies …