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This article employs a mixed‐method approach to examine the outcomes produced by using Twitter in a large‐lecture course as a means to assess the pedagogical impact and potential of Twitter’s contribution to large‐lecture course dynamics. In doing so, it seeks also to explore the broader relationship between methodologies and outcomes. Exploratory in nature and design, this study proceeds from the recognition of the inherent limitations and unpredictability in investigating how new technologies transform social patterns. Such an approach allows us to question how the mode and design of our research ultimately frame the interpretation and understanding of how social media intersect and impact classroom dynamics and their potential contributions for developing more effective pedagogical strategies and outcomes.