Autores
Andrew J Mungall, SA Palmer, SK Sims, CA Edwards, JL Ashurst, L Wilming, MC Jones, R Horton, SE Hunt, CE Scott, JGR Gilbert, ME Clamp, G Bethel, S Milne, R Ainscough, JP Almeida, KD Ambrose, TD Andrews, RIS Ashwell, AK Babbage, CL Bagguley, J Bailey, R Banerjee, DJ Barker, KF Barlow, K Bates, DM Beare, H Beasley, O Beasley, CP Bird, S Blakey, S Bray-Allen, J Brook, AJ Brown, JY Brown, DC Burford, W Burrill, J Burton, C Carder, NP Carter, JC Chapman, SY Clark, G Clark, CM Clee, S Clegg, V Cobley, RE Collier, JE Collins, LK Colman, NR Corby, GJ Coville, KM Culley, P Dhami, J Davies, M Dunn, ME Earthrowl, AE Ellington, KA Evans, L Faulkner, MD Francis, A Frankish, J Frankland, L French, P Garner, J Garnett, MJR Ghori, LM Gilby, CJ Gillson, RJ Glithero, DV Grafham, M Grant, S Gribble, C Griffiths, M Griffiths, R Hall, KS Halls, S Hammond, JL Harley, EA Hart, PD Heath, R Heathcott, SJ Holmes, PJ Howden, KL Howe, GR Howell, E Huckle, SJ Humphray, MD Humphries, AR Hunt, CM Johnson, AA Joy, M Kay, SJ Keenan, AM Kimberley, A King, GK Laird, C Langford, S Lawlor, DA Leongamornlert, M Leversha, CR Lloyd, DM Lloyd, JE Loveland, J Lovell, S Martin, M Mashreghi-Mohammadi, GL Maslen, L Matthews, OT McCann, SJ McLaren, K McLay, A McMurray, MJF Moore, JC Mullikin, D Niblett, T Nickerson, KL Novik, K Oliver, EK Overton-Larty, A Parker, R Patel, AV Pearce, AI Peck, B Phillimore, S Phillips, RW Plumb, KM Porter, Y Ramsey, SA Ranby, CM Rice, MT Ross, SM Searle, HK Sehra, E Sheridan, CD Skuce, S Smith, M Smith, L Spraggon, SL Squares, CA Steward, N Sycamore, G Tamlyn-Hall, J Tester, AJ Theaker, DW Thomas, A Thorpe, A Tracey, A Tromans, B Tubby, M Wall
Fecha de publicación
2003/10/23
Revista
Nature
Volumen
425
Número
6960
Páginas
805-811
Editor
Nature Publishing Group UK
Descripción
Chromosome 6 is a metacentric chromosome that constitutes about 6% of the human genome. The finished sequence comprises 166,880,988 base pairs, representing the largest chromosome sequenced so far. The entire sequence has been subjected to high-quality manual annotation, resulting in the evidence-supported identification of 1,557 genes and 633 pseudogenes. Here we report that at least 96% of the protein-coding genes have been identified, as assessed by multi-species comparative sequence analysis, and provide evidence for the presence of further, otherwise unsupported exons/genes. Among these are genes directly implicated in cancer, schizophrenia, autoimmunity and many other diseases. Chromosome 6 harbours the largest transfer RNA gene cluster in the genome; we show that this cluster co-localizes with a region of high transcriptional activity. Within the essential immune loci of the …
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Artículos de Google Académico
AJ Mungall, SA Palmer, SK Sims, CA Edwards… - Nature, 2003